The role of polymorphism of AGT genes (rs4762) and GNB3 (rs5443) in the development of essential hypertension

Assess the role of polymorphism AGT genes (rs4762) and GNB3 (rs5443) in development essential arterial hypertension separately by combining their polymorphic variants.Material methods. The case-control study involved 100 patients with EAH stage II, 1-3 degrees blood pressure (BP), high very cardiovascular risk. Among patients, 21% (21) constituted men, 79%(79) were women. mean age was 59.86±6.22 y.o. control group comprised 60 almost healthy individuals, relevant (49.13±6.28y.o.) gender distribution (63% - women, 37% men). To genes, we performed a qualitative polymerase chain reaction (PCR) real time.Results. In EAG residents Northern Bukovyna mutated T-allele gene is found 15,97% cases, which more frequent than practically 9,72% (p=0,023); mutations homozygous species have not met at all. Binary logistic regression confirmed an increase risk inheriting according to dominant additive models carriers minor 3 times higher homozygotes for major C-allele (р=0,04 і р=0,03). Inheritance associated variants (rs5443).
 Conclusions. Тhe increases times, while are predictors emergence population.